• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    device for delivering medicine. the present invention relates to a medication delivery device comprising a housing (10) adapted to receive a medication container (24); a drive element (48) movable from a first position to a second position such that medicine is allowed to be expelled through the supply element (28); an engagement element (46) movable between a locking position, and a release position, the device having an indication to show that it has been used provided by the actuating element (48) being retained in its second position. the invention is characterized by the fact that the actuating element comprises at least one locking projection (58) and the actuating mechanism comprises corresponding locking surfaces (64) against which the locking projections (58) lock when the drive (48) is in its second position.
    公开号:BR112015007571B1
    申请号:R112015007571-1
    申请日:2013-09-30
    公开日:2021-08-10
    发明作者:Anders Holmqvist
    申请人:Shl Medical Ag；
    IPC主号:
    专利说明:

    TECHNICAL AREA
    [0001] The present invention relates to a device for delivering medicine and in particular to a device endowed with security features to provide an intended user with information on the status of the device. BACKGROUND OF THE INVENTION
    [0002] Drug delivery devices for automatic or semi-automatic drug injection have been known for many years. Although the first generations of injectors were merely designed to deliver a drug as quickly as possible, the increased use of the devices by patients in non-clinical settings has led to the need to provide additional handling and safety functions.
    [0003] Important handling and safety functions of drug delivery devices include inhibiting premature device activation (failure). To ensure that the drug is properly injected, device triggering is inhibited until the auto-injector is correctly positioned in a dose delivery site. In addition, since the drug-delivering element can be sharp and can be contaminated after triggering the device, devices that retract or cover the drug-delivering element when the device is withdrawn from the dose delivery site have been developed. . To prevent a person from unintentionally making contact with the drug delivery element and to allow for safe disposal of the device, some devices feature a mechanism that locks the device after the drug delivery element is covered or retracted.
    [0004] Another important feature with medication delivery devices is to avoid the risk of using, or attempting to use, devices that have already been used, that is, ensuring that an intended user is provided with information regarding the status of the device, and also provide inhibiting characteristics after use of a drug delivery device. Many medication delivery devices are arranged with some type of actuation mechanism, often including a push button or the like. Such tamping buttons are often positioned at a distal end of the device, farthest away from a dose delivery location such that a finger, often a thumb, can operate the button while holding the device. Such an arrangement is disclosed in EP 850079, in which a so-called pen injector is disclosed having a dose adjustment mechanism comprising a dose adjustment knob at a distal end of the device. By turning the dose adjustment knob a dose of medication is adjusted. To deliver the dose, the dose adjustment knob is pressed in the proximal direction to an extreme position where it is axially locked. When a subsequent dose is to be delivered, the dose adjustment knob is again turned, whereby it is unlocked and moved in the distal direction.
    [0005] The device according to EP 850079 is intended for multiple doses, and therefore the dose adjustment knob has to be returned to its initial position. Although locked after dose delivery, it is easy to unlock the button for the subsequent dose. For a drug delivery device that is intended for a single dose, it should not be possible to manipulate the device in such a way that the dose knob can be returned. A user could then have the impression that the device has not been used and may attempt to administer a dose with a used device. If the user does not have access to another drug delivery device, he may unexpectedly find himself without delivery devices to fulfill a medication schedule.
    [0006] As shown above, available drug delivery devices do not provide the necessary handling, security and information functions or require the cooperation of one or more complex mechanisms. Therefore, there is a need for drug delivery devices that comprise mechanisms that provide some or all of these functions in a secure mode, with as few parts as possible. This is especially important for single-use devices where low manufacturing cost is a necessity. BRIEF DESCRIPTION OF THE INVENTION
    [0007] In the present application, when the term “distal” is used, it refers to the direction pointing in the opposite direction from the dose delivery site. When the term "part/distal end" is used, it refers to the part/end of the delivery device, or the parts/ends of elements thereof, which is/are located farthest away from the delivery location of dose. Correspondingly, when the term “proximal” is used, it refers to the direction that points to the dose delivery site. When the term "end/proximal part" is used, it refers to the part/end of the delivery device, or the parts/ends of elements thereof, which is/are located closest to the dose delivery location.
    [0008] The objective of the present invention is to remedy the above mentioned disadvantages with the devices for delivering medication of the state of the art. This objective is achieved with a device for delivering medicine in accordance with the characteristics of the independent patent claims. Preferable embodiments of the invention form the subject of the dependent patent claims.
    [0009] According to a preferable solution, the present invention relates to a device for delivering medicine, comprising a housing adapted to receive a container of medicine. The medicine container can have a number of designs and can be a number of sizes, depending on the intended use and type of medicine. A suitable medicine supply element may be arranged in the medicine container. The supply element may be an integral part of the medicine container or it may be a pluggable supply element.
    [00010] Furthermore, the element for delivering medicine can be of a number of designs depending on the function and type of medicine desired, such as nozzles, mouthpieces, nebulizers, or injection needles, to name a few.
    [00011] The device for delivering medicine according to the invention may preferably comprise a drive mechanism which is actuated and in turn acts on the medicine container. In that regard there may be a number of different designs which are understood by a person skilled in the art which can be used to perform a drive function to actuate the medicine container whereby a dose of medicine is delivered. These include different types of media with accumulated energy, such as gas spring or mechanical media, to name but a few.
    [00012] Preferably, the device for delivering medicine may further comprise a drive element. It can be moveable from a first position, in which it allows the drive mechanism to be retained, to a second position, in which it allows the drive mechanism to be released. When the drive mechanism is released, the drug is allowed to be expelled through the supply element. The drive element can be of different designs. A preferred design is a tamper button that can be disposed at the distal end of the medication delivery device and arranged to be tamped into the housing of the device when the dose is to be delivered.
    [00013] According to a feasible solution of the invention, it may further comprise a movable engagement element between a locking position, in which it prevents movement of the drive element from its first position to its second position, and a release position , which allows movement of the drive element from its first position to its second position. This solution ensures that the drive element cannot be moved until the engagement element has been activated. Activation of the engagement element can be performed by different actions. A preferred action may be for the engagement element to be arranged with notches in which protrusions of the drive element are positioned, where the engagement element can be rotated such that the protrusions of the drive element are positioned such that the element drive can be moved to the second position. Other feasible actions may be to compress the drug delivery device against a dose delivery location, the action of which moves the engagement member out of locking engagement with the drive member.
    [00014] Furthermore, the device may have an indicator to show that it has been used and this is preferably provided by the drive element being held in its second position.
    [00015] According to a preferable solution of the invention, it can be characterized by the fact that the actuating element comprises at least one locking projection and the actuating mechanism comprises corresponding locking surfaces against which the locking projections lock when the drive element is in its second position. With this solution it can be ensured that the drive element is held securely in the second position, with the advantages that there is a clear and positive indication that the device has been used because the user immediately sees that the drive element is tamped down. Again, the locking mechanism ensures that it is very difficult to manipulate the actuating element. Instead, it is securely locked into the second position within the housing of the medication delivery device.
    [00016] According to a preferred solution of the invention, at least one locking projection comprises at least one flexible section and an end surface facing the distal direction of the device.
    [00017] Furthermore, at least one locking projection is integrated into proximally oriented arms of the drive element.
    [00018] Additionally, the locking surfaces are facing in the proximal direction of the device, such that the surfaces are placed in locking engagement when the drive element is in its second position.
    [00019] According to one aspect of the invention, the annular boss is arranged with cutouts having side surfaces and through which the proximally oriented arms of the drive element can extend.
    [00020] According to a further aspect of the invention, at least one locking projection is configured to be biased by the side surfaces when the drive element is moved a certain distance from the first position to the second position and in such a way that when the end surface of at least one locking projection has passed through the cutouts, the flexible section will bend backward at least one locking projection whereby the end surface of at least one locking projection locks with the proximally oriented surfaces of the annular shoulder .
    [00021] According to another aspect of the invention, the actuation element comprises a generally tubular distal part forming a press button provided through the engagement element, the generally tubular distal part comprises protrusions on its outer surface configured to fit into extended notches transversely and longitudinally of the engagement element.
    [00022] According to yet another aspect of the invention, the engagement element is in the locking position when the protrusions are positioned in the transversely extended notches and the engagement element is in the release position when the protrusions are positioned in line with the notches extended lengthwise.
    [00023] According to a further aspect of the invention, the retaining element comprises at least one distally oriented arm which can be flexible in the radial direction and wherein at least one distally oriented arm can be arranged with hooks oriented towards inside designed to fit into cutouts or direct holes in the plunger rod and outwardly oriented protrusions designed to interact with the inner surface of the drive element and with direct holes in the drive element.
    [00024] According to another aspect of the invention, the actuating element is in the first position when the actuating element is arranged surrounding the distally oriented arms such that the hooks are engaged in the cutouts or direct holes of the piston rod .
    [00025] According to yet another aspect of the invention, the drive element is in the second position when the press button is fully positioned on the engagement element such that the protrusions are allowed to enter the direct holes whereby the arms are left be moved radially outward to allow the hooks to come out of engagement with the piston rod.
    [00026] According to a further aspect of the invention, the drug delivery device is an injection device and more particularly a pen injector or an autoinjector.
    [00027] These and other aspects, and advantages of the present invention will become apparent from the following detailed description of the invention and from the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS
    [00028] In the following detailed description of the invention, reference will be made to the attached drawings, of which
    [00029] Figure 1 is a perspective view of a device for delivering medication according to the present invention,
    [00030] Figure 2 is a detailed view of the device according to Figure 1,
    [00031] Figure 3 is a detailed view of a part of the device of Figure 1,
    [00032] Figure 4 is a cross-sectional view of the device of Figure 1, and
    [00033] Figures 5-7 are detailed views showing different functional states of the device in figure 1.
    [00034] Figures 8-9 are detailed views showing different functional states of a variant of the mode of figure 1. DETAILED DESCRIPTION OF THE INVENTION
    [00035] Figure 1 shows a perspective view of a device for delivering medication according to the present invention. The device comprises an elongated generally cylindrical housing 10 having a proximal and a distal end as viewed along a longitudinal axis L of the device. The proximal end of the device can be additionally arranged with a protective cap 20.
    [00036] Figure 2 shows a detailed view of the device according to figure 1. A protector 14 or glove-like structure, figure 2, is arranged sliding in the longitudinal direction inside the housing and through a proximal end passage. Guard 14 may be arranged with distally oriented arms 15, each arm being arranged with tabs 16 at its distal ends. The housing is adapted to receive a medicine container 24 with or without a connectable supply element 28. A medicine container holder 22 is disposed in the housing and configured to receive the medicine container 24. The medicine container holder may be partially disposed on the shield 14 such that the shield is slidable relative to both the medication container holder and the housing. The medicine container 24 may comprise a movable stop 26, Fig. 4, and a medicine supply element 28. However, as mentioned above, the medicine supply element 28 does not have to form part of the medicine container and may be a device independent element. As shown in Figure 2, the drug delivery element may be a needle. A spring guard 18 may be disposed between the proximal end of the medication container holder 22 and an annular shoulder on the inner surface at the proximal end of the guard to bias the guard 14 in the proximal direction. It is also possible that the protective spring 18 could be disposed between an annular shoulder on the inner surface of the housing and an annular shoulder on the inner surface at the proximal end of the guard.
    [00037] A side surface of the medicine container holder 22 can be arranged with a locking mechanism 30, figures 2 and 3. The locking mechanism 30 comprises at least one lever. The lever could be a rocker arm. The lever may be in the form of a longitudinally extending beam 32. The beam 32 may be connected therebetween to the medication container holder 22 by two pivot arms, creating a proximal end and a distal end. The beam may be formed integral with the medication container support 22 or pivotally engaged thereto. The distal end of beam 32 may be disposed with a transversely extending shoulder 34, Fig. 3. Guard 14 may be disposed in such relationship to beam 32 that tongues 16 are aligned along the sides of beam 32, as will be further explained. below.
    [00038] In addition, the device may be provided with a drive mechanism 50 comprising a drive locking element 36, an engagement element 46 in the form of a guide sleeve, and a drive element 48. drive 36 may comprise a generally ring-shaped or glove-shaped element 38 surrounding the medication container holder 22 and positioned distally to beam 32, Fig. 3. The ring-shaped element 38 may have at least a proximally extending tongue 40 disposed in line with the beam 32. The ring-shaped element 38 may be additionally arranged with distally oriented arms 42. In the embodiment shown, the ring-shaped element 38 comprises two shaped arms. distal 2. As shown in Figure 3, the distal portions of the arms 42 may extend into longitudinal cutouts or notches 44 of the engagement element 46. The drive element 48 may be provided via engagement element 46. Actuation element 48 may comprise a generally tubular distal portion disposed with protrusions 52 on its outer surface, which protrusions 52 engage with notches 44 of engagement element 46 as well as with notches extending transversely 47 on the engagement element 46, forming an engagement connection. The tubular part of the actuating element 48 can extend in the distal direction forming a depressing button 54, which projects through the engagement element in the distal direction. Direct holes 39 are arranged in the tubular part of the drive element 48, the function of which will be explained below. The connection between the engaging element 46 and housing is such that the engaging element is prevented from being disengaged from the housing, but allowed to be rotated relative to the housing. The connection between the engagement element and the drive element 48 is such that the drive element is allowed to be moved, more particularly axially slidable, with respect to the engagement element. The engagement element is also allowed to be rotated relative to the drive element.
    [00039] The drive element 48 comprises at least one locking projection 58 pointing in a generally distal direction, but with a certain inclination to the longitudinal axis L of the device. At least one locking projection 58 is in the embodiment shown, Figure 6, integrated into the proximally oriented arms 60 of the tubular element 48. Each locking projection 48 comprises at least one flexible section 62 and an end surface 63, the latter facing the distal direction of the device.
    [00040] The device may additionally be provided with a drive mechanism 90 comprising a retaining element 70, a plunger element or an elongated plunger rod 72, a drive spring 74, and a signal generating element 76, figures 2 and 4. Plunger rod 72 may be provided with a hollow space in which actuating spring 74 is arranged to spring biases piston rod 72. The proximal end of elongated plunger rod 72 may be in contact with the anvil 26 of the medicament container 24. A distal end of the drive spring 74 may be in contact with a transverse portion of the signal generating element 76 which has a general U-shape. The signal generating element 76 may have proximally oriented legs and each leg may comprise a radially outwardly extending shoulder. The signal generating element 76 may be configured to partially surround the spring loaded plunger rod. The retaining element 70 comprises at least one, and more particularly two, distally oriented arms 78 which can be flexible in the radial direction. The distal ends of the arms 78 can be arranged with inwardly oriented hooks 80 and outwardly oriented protrusions 79. The hooks 80 can be designed to fit into cutouts or direct holes 82 of the plunger rod 72 to hold it in position, Fig. 4 , as will be explained. The protrusions 79 can be designed to interact with the inner surface of the tubular portion of the drive element 48 and with the through holes 39 disposed in the tubular portion of the drive element 48. The signal generating element 76 can be axially disposed across the retaining element 70. The proximally oriented arms 60 of drive element 48 may extend axially and slidably along notches 66 in the outer surface of the retaining element.
    [00041] In addition, the drive element 48 is configured to be movable from a first position, in which it allows the drive mechanism to be retained, to a second position, in which it allows the drive mechanism 90 to be released such that the drug is allowed to be expelled through the supply element 28. The actuation element is in the first position when the actuation element is disposed surrounding the distally oriented arms 78 such that the hooks 80 are engaged in the cutouts or direct holes 82 of the piston rod, and the protrusions 52 are aligned with the transverse notches 47. The actuating element is in the second position when the depress button 54 is fully positioned on the engagement element such that the protrusions 79 are allowed to enter the direct holes 39 of the drive element, i.e. the direct holes 39 are aligned with the protuberances 39 whereby the arms 78 are left to be moved radially outward to allow the hooks 80 to come out of engagement with the piston rod.
    [00042] In addition, the engagement element 46 is configured to be movable between a locking position, in which it prevents movement of the drive element 48 from its first position to its second position, and a release position, in which allows movement of drive element 48 from its first position to its second position. The device has an indicator to show that it has been used, provided by the actuating element 48 being held in its second position.
    [00043] The engagement element 46 is in the locking position when the protrusions 52 are positioned in the transversely extended notches 47. The engagement element 46 is in the release position when the protrusions 52 are positioned in line with the longitudinally extended notches 44.
    [00044] When the drive mechanism is assembled, the drive spring 74 can be compressed between a proximal inner end surface of the plunger rod 72 and the transverse portion of the signal generating element 76. The radially outwardly extending lugs of the element generating elements 76 can be engaged with the proximal annular surface of the retaining element 70 to prevent the signal generating element 76 from being moved in the distal direction by the drive spring 74. The piston rod is thereby spring-biased in the proximal direction. As discussed above, the actuating element 48 may be arranged surrounding the distally oriented arms 78 such that the hooks 80 are engaged in a corresponding engagement with a cutout 82 in the spring actuated piston rod. This means that the drive element 48 is in the first position, in which it allows the drive mechanism to be retained. The protrusions 52 of the drive element 48 are positioned in the notches 44 of the engagement element 46 such that the engagement element 46 is in the locking position, in which it prevents movement of the drive element 48 from its first position to its second position. Arms 42 extend into longitudinal notches 44 of engagement element 46 on proximally oriented arms 60 of drive element 48 such that the distal end surfaces of arms 42 are in line with the proximal edge of the transverse notches. 47 of the engagement element 46.
    [00045] The distally oriented surfaces 63 of the locking projections 58 are arranged to cooperate with the locking surfaces 64 of the drive mechanism. More particularly, the locking surfaces 64 may be proximally oriented surfaces of an annular boss 68 on the outer surface of the retaining element 70. The annular boss 68 is arranged with cutouts having side surfaces 65 through which cutouts the shaped arms are oriented. proximal 60 of drive element 48 may extend. More particularly, the locking surfaces 64 face towards the proximal direction of the device.
    [00046] The device is intended to function as follows. When the device is to be used, the protective cap 20 is removed. To perform a dose delivery, the device has to be activated, which is done by rotating the engaging element 46 with respect to the actuating element 48. This causes the transverse notches 47 to slide with respect to the protrusions 52 until the protrusions 52 are in line with the longitudinal notches 44 of the engagement member 46 such that the protrusions 52 abut the distal end surfaces of the arms 42. This means that the engagement member 46 has been moved from the locking position, in which it prevents movement of the drive element 48 from its first position to its second position, to the release position, in which it allows movement of the drive element 48 from its first position to its second position. However, the press button 54 is prevented from being depressed as the proximally oriented tabs 40 abut the shoulder 34. To allow the press button to be pressed, the proximal end of the shield 14 needs to be pressed against the dose delivery site. This causes the shield 14 axially to slide towards the distal direction of the device relative to the housing and the container holder whereby the distally oriented tabs 16 will be moved in contact with the shoulder 34. Since the shoulder 34 is in wedge shape, pawls 16 will slide over shoulder 34, exerting a radial force on shoulder 34 and thereby on the distal end of beam 32, deflecting the distal end of the beam, along with shoulder, radially inward.
    [00047] After boss 34 has been moved radially inward, the proximally oriented tabs 40 of drive locking element 36 no longer abut shoulder 34 allowing drive locking element 36 to be moved in the proximal direction. Thus when the press button 54 is pressed in the proximal direction, the protrusions 52 are guided into the longitudinal notches 44. Since the protrusions 52 are abutting the distal end surfaces of the arms 42, the ring-shaped element 38 is moved in the proximal direction, Figure 4. In addition, displacement of the press button 54 towards the proximal end of the device, such that the press button is fully positioned on the engagement element 46, allows the protrusions 79 to enter the through holes 39 such that the arms 78 are moved radially outward allowing the hooks 80 to come out of engagement with the piston rod 72. This means that the actuating element is in the second position. Having the press button fully positioned on the latch element 46 means that no part of the press button protrudes distally from the latch element, i.e. the transverse distal outer surface of the press button is flush with the distal annular edge of the latch element. engagement 46. Plunger rod 72 may, upon disengagement of hooks 80, be biased in the proximal direction by actuating spring 74 and may act on stop 26 within medication container 24 to deliver a dose of medication through the delivery member. of drug 28 at the dose delivery site. This means that the drive element 48 has been moved from the first position, in which it allows the drive mechanism 90 to be retained, to a second position, in which it allows the drive mechanism 90 to be released, such that the medicament is expelled through the supply element 28. Proximal movement of the ring-shaped element 38 causes the proximally oriented tabs 40 to move in the proximal direction, whereby they can be moved radially away from the shoulder 34 in such a way. that the shoulder is retained, pressed inwards in the radial direction.
    [00048] According to the invention, when the press button 54 is moved in the proximal direction, so are the arms 60 with the locking projections 58. The locking projections will slide along, and will be biased by the side surfaces 65, figures 6 and 7 of the cutouts in the annular shoulder 68 on the outer surface of the retaining element 70. When the press button 54 was pressed a distance in the proximal direction, the distal end surfaces 63 of the locking projections 58 passed through the cutouts, the sections flexible 62 will induce the locking projections 58 back to their initial position. Now, as seen in Figure 7, the distally oriented end surfaces 63 of the locking projections 58 are abutting the proximally oriented surfaces 64 of the annular shoulder 68. This means that the locking projections 58 of the actuating element and the corresponding locking surfaces 64 of the drive mechanism lock when the drive element 48 is in its second position.
    [00049] In that position, the dose of medicine has been delivered, which is indicated by the actuating element 48 and thereby the press button 54 being held in the second, depressed position. It is thus obvious that the device has been used and has to be discarded. In that regard, the side surface of the press button 54 may be arranged with coloring indicating an unused, or ready-to-use device, while, in the used position, the coloring is no longer visible once the press button 54 is inside. of housing 10. This means that the device, or more particularly the drive element, has an indicator to show that the device has been used.
    [00050] When the dose has been delivered, the device can be withdrawn from the dose delivery site. This in turn causes the shield 14 to be moved in a proximal direction, relative to the housing and the container holder, by the protective spring 18. The proximal movement of the shield 14 will cause the proximal end of the beam 32 to be released, whereby the latter will flex outwards in the radial direction due to the tension built up in the beam 32 by the proximally oriented lugs 40 when moved over the shoulders 34. The beam 32 can thereby reach a final position at which the proximal end of the beam 32 limits the movement of guard 14 in the distal direction. The proximal end of the longitudinal beam 32 can be positioned between the distally oriented tabs 16 of the shield 14, locking the shield 14 against movement in the distal direction and allowing the device to be safely disposed of.
    [00051] Figures 8-9 show a variant of the locking surface 64 and locking projection 64 for the present invention in which the distal contact surface 100 of the annular shoulder 68 according to figure 6 is arranged with an inclined section 104 Furthermore, the locking projection 58 is arranged with a cutout or notch 102. Thereby, during actuation of the press button 54, the notch 102 in the locking projection 58 is induced to engage the slanted section 104 of the annular shoulder 68 of such that the contact between the notch 102 and the end surface of the sloped section 104 will elastically push the locking projection 58 aside and then cause it to recoil against the sloped section 104 to provide audible and tactile information to the user of the progress of the dose delivery sequence. Also as with the previous variant, the device actuating element 48 is prevented from moving from its second position. Furthermore, in the variant shown in Figures 8 and 9, the locking projection 58 has an increased thickness t to further secure the device drive element 48 in its second position.
    [00052] Although the invention has been illustrated and described in detail in the above drawings and description, such illustration and description are to be considered illustrative or exemplary and not restrictive. It will be understood that changes and modifications may be made by those with common knowledge within the scope of the following claims. In particular, the present invention covers additional embodiments with any combination of features from different embodiments described above and below.
    [00053] Furthermore, in the claims the word "comprising" does not exclude other elements or steps, and the indefinite article "a" or "an" does not exclude a plurality. A single unit can fulfill the functions of various characteristics mentioned in the claims the terms “essentially”, “about”, “approximately” and the like with respect to an attribute or a particularly value also define exactly the attribute or exactly the value, respectively. Any reference signs in the claims are not to be interpreted as limiting the scope.
    权利要求:
    Claims (17)
    [0001]
    1. A device for delivering a medicine, comprising: - a housing (10) adapted to receive a medicine container (24) with or without a connectable supply element (28); - a drive mechanism (90) which is actuated and in turn acts on the medicine container (24); - a drive element (48) movable from a first position, in which it allows the drive mechanism (90) to be retained, to a second position, in which allows the drive mechanism (90) to be released in such a way that the medicine is allowed to be expelled through the supply element (28); - an engaging element (46) movable between a locking position, in which it prevents movement of the drive element (48) from its first position to its second position, and a release position, in which it allows movement of the drive element (48) from its first position to its second position, the device having a indicator for most rar that was used supplied by the drive element (48) being held in its second position; characterized in that the actuating element comprises at least one locking projection (58) and the actuating mechanism comprises corresponding locking surfaces (64) against which the locking projections (58) lock when the actuating element (48 ) is in its second position.
    [0002]
    2. Device for delivering medication, according to claim 1, characterized in that at least one locking projection (58) comprises at least one flexible section (62) and an end surface (63) facing the distal direction of the device.
    [0003]
    3. Device for delivering medicine, according to claim 2, characterized in that at least one locking projection (58) is integrated in proximally oriented arms (60) of the drive element (48).
    [0004]
    4. Device for delivering medicine according to claim 3, characterized in that the locking surfaces (64) are facing in the proximal direction of the device, such that the surfaces (63, 64) are placed in engagement when the drive element (48) is in its second position.
    [0005]
    5. Device for delivering medicine according to claim 4, characterized in that the drive mechanism (90) comprises a retaining element (70), a piston element (72), a drive spring (74 ) and a signal generating element (76).
    [0006]
    6. A drug delivery device according to claim 5, characterized in that the locking surfaces (64) are proximally oriented surfaces of an annular shoulder (68) on the outer surface of the retaining element (70) .
    [0007]
    7. Device for delivering medicine according to claim 6, characterized in that the annular boss (68) is arranged with cutouts having side surfaces (65) and through which the proximally oriented arms (60) of the drive element (48) can extend.
    [0008]
    8. Device for delivering medicine according to claim 7, characterized in that at least one locking projection (58) is configured to be protruding by the side surfaces (65) when the drive element (48) is moved a certain distance from the first position to the second position and such that when the end surface (63) of at least one locking projection (58) has passed through the cutouts, the flexible section (62) will bend backwards at least one locking projection (58) whereby the end surface 63 of the at least one locking projection (58) locks with the proximally oriented surfaces (64) of the annular shoulder (68).
    [0009]
    9. Device for delivering medication according to claim 8, characterized in that at least one locking projection (58) is arranged with a notch (102) arranged to provide tactile and audible responses as it passes through the side surface ( 65).
    [0010]
    10. Device for delivering medicine, according to claim 9, characterized in that the side surface (65) is arranged with an inclined section (104).
    [0011]
    11. Device for delivering medicine, according to any one of the preceding claims, characterized in that the actuating element (48) comprises a generally tubular distal part forming a press button (54) provided through the engagement element ( 46), the generally tubular distal portion comprises protrusions (52) on its outer surface configured to engage transversely (47) and longitudinally (44) extending notches of the engagement element (46).
    [0012]
    12. Device for delivering medication according to claim 11, characterized in that the engagement element (46) is in the locking position when the protrusions (52) are positioned in the transversely extended notches (47) and the engaging element (46) is in the release position when the protrusions (52) are positioned in line with the longitudinally extending notches (44).
    [0013]
    13. Device for delivering medicine according to any one of claims 5-8, characterized in that the retaining element (70) comprises at least one distally oriented arm (78) which can be flexible in the radial direction and wherein at least one distally oriented arm (78) may be arranged with inwardly oriented hooks (80) designed to engage in cutouts or direct holes (82) of the plunger rod (72) and outwardly oriented protrusions (79 ) designed to interact with the inner surface of the drive element (48) and with direct holes (39) of the drive element (48) .
    [0014]
    14. Device for delivering medicine according to claim 13, characterized in that the drive element (48) is in the first position when the drive element is arranged surrounding the distally oriented arms (78) of such so that the hooks (80) are engaged in the cutouts or direct holes (82) of the piston rod (72).
    [0015]
    15. Device for delivering medication according to claim 13 or 14, characterized in that the actuating element (48) is in the second position when the press button (54) is fully positioned on the engagement element (46 ) such that the protrusions (79) are allowed to enter the direct holes (39) whereby the arms (78) are allowed to be moved radially outward to allow the hooks (80) to come out of engagement with the piston rod ( 72).
    [0016]
    16. Device for delivering medicine, according to any one of the preceding claims, characterized in that the device for delivering medicine is an injection device.
    [0017]
    17. Device for delivering medicine, according to claim 7, characterized in that the injection device is a pen injector or an auto-injector.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112015007571B1|2021-08-10|DEVICE FOR DRUG SUPPLY
    JP5475688B2|2014-04-16|Pen-type injection needle assembly with insertion needle
    US20200101235A1|2020-04-02|Medicament Delivery Device Comprising a Locking Mechanism Having a Lever
    US20190046728A1|2019-02-14|Push Button Safety Injector
    US8945065B2|2015-02-03|Syringe safety assembly
    JP2019528834A|2019-10-17|Needle assembly for hypodermic injection set
    KR102105750B1|2020-04-29|Drug delivery device
    RU2598809C1|2016-09-27|Device for drug delivery
    US20200238014A1|2020-07-30|Semi-reusable palm activated injector system
    ES2802154T3|2021-01-15|Drug delivery device comprising a locking mechanism having a lever
    BR112015026493B1|2022-02-08|DRUG ADMINISTRATION DEVICE INCLUDING A LOCKING MECHANISM
    同族专利:
    公开号 | 公开日
    WO2014053451A1|2014-04-10|
    TW201431577A|2014-08-16|
    EP2903670A1|2015-08-12|
    CN104780962A|2015-07-15|
    CA2886304A1|2014-04-10|
    US20150273162A1|2015-10-01|
    AU2013326601A1|2015-04-23|
    JP6140829B2|2017-05-31|
    KR20150067255A|2015-06-17|
    KR101716593B1|2017-03-27|
    EP2903670B1|2017-04-19|
    CA2886304C|2017-06-13|
    DK2903670T3|2017-06-26|
    JP2015533562A|2015-11-26|
    AU2013326601B2|2016-07-21|
    TWI568468B|2017-02-01|
    BR112015007571A2|2017-07-04|
    US10314987B2|2019-06-11|
    CN104780962B|2017-09-01|
    ES2627823T3|2017-07-31|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    AU1860697A|1995-09-08|1997-07-28|Visionary Medical Products Corporation|Pen-type injector drive mechanism|
    US20030105430A1|2001-11-30|2003-06-05|Elan Pharma International Limited Wil House|Automatic injector|
    US20050101919A1|2003-11-07|2005-05-12|Lennart Brunnberg|Device for an injector|
    JP5400770B2|2007-07-06|2014-01-29|ノボ・ノルデイスク・エー／エス|Automatic syringe|
    CN101909674B|2007-11-12|2013-04-10|邦奥鲁夫森梅迪康股份有限公司|Auto injector with automatic needle retraction|
    US8814834B2|2008-03-10|2014-08-26|Antares Pharma, Inc.|Injector safety device|
    GB0900930D0|2009-01-20|2009-03-04|Future Injection Technologies Ltd|Injection device|
    US8414533B2|2009-10-08|2013-04-09|Shl Group Ab|Medicament delivery device|
    EA023390B1|2009-10-16|2016-05-31|Янссен Байотек, Инк.|Palm activated drug delivery device|
    WO2012030276A1|2010-08-31|2012-03-08|Shl Group Ab|Medicament delivery device|
    EP2468336A1|2010-12-21|2012-06-27|Sanofi-Aventis Deutschland GmbH|Auto-injector|
    EP2468330A1|2010-12-21|2012-06-27|Sanofi-Aventis Deutschland GmbH|Auto-injector|US8548623B2|2009-03-18|2013-10-01|Acelrx Pharmaceuticals, Inc.|Storage and dispensing devices for administration of oral transmucosal dosage forms|
    PL234202B1|2013-09-30|2020-01-31|Htl Strefa Spolka Akcyjna|Safety needle device|
    USD770611S1|2014-03-07|2016-11-01|Aptar France Sas|Medicine injector|
    JP1532502S|2014-07-11|2015-08-31|
    JP1532501S|2014-07-11|2015-08-31|
    DK3316929T3|2015-07-03|2021-07-26|Shl Medical Ag|MEDICINE SUPPLY DEVICE|
    GB2541227A|2015-08-13|2017-02-15|Owen Mumford Ltd|Injector Device|
    US10632259B2|2015-08-26|2020-04-28|Shl Medical Ag|Medicament delivery device and assembly of electronic device and the medicament delivery device|
    GB2541915A|2015-09-03|2017-03-08|Owen Mumford Ltd|Medicament delivery devices|
    EP3141275A1|2015-09-14|2017-03-15|Carebay Europe Ltd.|Medicament delivery device|
    GB2543274A|2015-10-12|2017-04-19|Owen Mumford Ltd|Injection device|
    EP3368097B1|2015-10-30|2020-03-18|AcelRx Pharmaceuticals, Inc.|Apparatus and methods for dispensing oral transmucosal dosage forms|
    US11116912B2|2015-11-20|2021-09-14|Shl Medical Ag|Needle shield mechanism and a medicament delivery device comprising the needle shield mechanism|
    WO2017102175A1|2015-12-14|2017-06-22|Carebay Europe Ltd|Medicament delivery device|
    WO2018041741A1|2016-08-30|2018-03-08|Sanofi-Aventis Deutschland Gmbh|Injection device|
    EP3326671A1|2016-11-29|2018-05-30|Carebay Europe Ltd.|Activation assembly for a medicament delivery device|
    CA3064671A1|2017-05-23|2018-11-29|Merck Patent Gmbh|Auto injector with recap prevention|
    CN108434556A|2018-05-23|2018-08-24|苏州鹏烨医疗科技有限公司|Injection pen|
    WO2019224783A1|2018-05-24|2019-11-28|Novartis Ag|Automatic drug delivery device|
    KR102219038B1|2020-12-11|2021-02-23|풍림파마텍|Disposable injection device with improved coupling structure between the locking module housed in the outer housing and the chemical cartridge containing the injection solution|
    KR102219035B1|2020-12-11|2021-02-23|풍림파마텍|Disposable injection device with locking structure to prevent reuse|
    KR102224517B1|2020-12-11|2021-03-09|풍림파마텍|Disposable injection device with improved locking structure between outer housing and locking module to prevent reuse|
    法律状态:
    2018-11-21| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2020-02-27| B25A| Requested transfer of rights approved|Owner name: SHL MEDICAL AG (CH) |
    2020-04-07| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-07-06| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-08-10| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/09/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201261710029P| true| 2012-10-05|2012-10-05|
    US61/710,029|2012-10-05|
    SE1251133|2012-10-05|
    SE1251133-3|2012-10-05|
    PCT/EP2013/070373|WO2014053451A1|2012-10-05|2013-09-30|Medicament delivery device|
    [返回顶部]